NDimension has the ability to conduct synergistic studies at the level of neural networks , using different multi-electrode array platforms, and single cells, utilising patch clamp techniques. Electrophysiological recordings may be obtained from cultured CNS neurons, hiPSC-derived neurons (including patient-specific), brain/spinal cord slices, and various sensory cells (pain: DRGs; auditory: spiral ganglion neurons and cochlear hair cells; ophthalmic: rodent and donated human retinal explants and hiPSC-derived retinal organoids).
In addition, we are currently developing capabilities to work with other excitable tissues (cardiac, detrusor smooth muscle, pancreatic β-cells/islets of Langerhans), genetically tractable model organisms (Drosophila melanogaster), and various cancer cells.
Notably, our laboratories are located in the centre of the rapidly developing and globally important Cambridge Biomedical Campus, the home of Addenbrooke’s and Papworth Hospitals, and a short walk from the site of the Cambridge South Railway Station, which will not only have direct links to Oxford, via the newly approved East West Rail Route, but also to Central London, Stansted Airport, and therefore Europe.
• Advanced preclinical in vitro electrophysiological research solutions, from neural networks to single cells
• Specialists in very long-term instrumented neural culture techniques (continuous recording)
• Bespoke electrophysiological assays, incorporating both conventional and novel drug exposure/electrical stimulation techniques
• Enabling biomedical technology development
• Basic fee-for-service: (i) hourly-rate, (ii) per compound tested, (iii) per data point.
• Project- or Master-Service-Agreements incorporating Work Packages to your requirements
• Partnering
• Study plans, experimental design, advanced data analysis
• Construction, equipping and running of electrophysiological facilities
Kurt Lewin